2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10545
    [D-His26]-Neuropeptide Y, human, rat
    		Agonist
    [D-His26]-Neuropeptide Y, human, rat is a synthetic variant of neuropeptide Y (NPY). [D-His26]-Neuropeptide Y, human, rat acts as a Y1R agonist that can prevent the development of anxiety, social impairment, and depressive symptoms, and has the potential to be used as an early intervention treatment for post-traumatic stress reactions.
    [D-His26]-Neuropeptide Y, human, rat
  • HY-107730
    NPY5RA-972
    		Antagonist 98.86%
    NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor.
    NPY5RA-972
  • HY-P1532
    Pancreatic Polypeptide, rat
    		Agonist
    Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.
    Pancreatic Polypeptide, rat
  • HY-P4805
    Peptide YY (13-36) (canine, mouse, porcine, rat)
    		Agonist
    Peptide YY (13-36) (canine, mouse, porcine, rat) is a Y2 receptor subtype agonist.
    Peptide YY (13-36) (canine, mouse, porcine, rat)
  • HY-P1305A
    CART(55-102)(rat) TFA
    CART(55-102)(rat) TFA is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) TFA is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) TFA can induces anxiety and stress-related behavior.
    CART(55-102)(rat) TFA
  • HY-107479
    (R)-JNJ-31020028
    		Antagonist
    (R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.
    (R)-JNJ-31020028
  • HY-P5896
    Ala5-Galanin (2-11)
    		Agonist
    Ala5-Galanin (2-11) is a galanin receptor 2 (GAL2R) specific agonist with a Ki of 258 nM.
    Ala5-Galanin (2-11)
  • HY-P3677
    Neuropeptide Y (2-36) (porcine)
    		Agonist
    Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC50 values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.
    Neuropeptide Y (2-36) (porcine)
  • HY-P4060
    Pancreatic polypeptide
    		98.81%
    Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion.
    Pancreatic polypeptide
  • HY-P1249A
    Neuropeptide SF(mouse,rat) TFA
    		Agonist
    Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
    Neuropeptide SF(mouse,rat) TFA
  • HY-P5064
    Galanin-Like Peptide (porcine)
    		Agonist
    Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide that was first isolated from the porcine hypothalamus. Galanin-Like Peptide (porcine) has a high affinity for the GALR2 receptor (IC50 of 0.24 nM) and a lower affinity for the GALR1 receptor (IC50 of 4.3 nM).
    Galanin-Like Peptide (porcine)
  • HY-P10290
    Neuropeptide Y (human) free acid
    Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling.
    Neuropeptide Y (human) free acid
  • HY-P3360
    Y4R agonist-2
    		Agonist
    Y4R agonist-2 is a Y4R agonist with a Ki of 0.033 nM.
    Y4R agonist-2
  • HY-RS09519
    Npy4r Rat Pre-designed siRNA Set A
    		Inhibitor

    Npy4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy4r Rat Pre-designed siRNA Set A
    Npy4r Rat Pre-designed siRNA Set A
  • HY-P1321
    GR231118
    		Antagonist
    GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8).
    GR231118
  • HY-120096
    BIBO3304 free base
    		Antagonist
    BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting.
    BIBO3304 free base
  • HY-107729
    Lu AA33810
    		Antagonist 98.3%
    Lu AA33810 is a potent and selective antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.
    Lu AA33810
  • HY-P1438A
    Neuropeptide S(Rat) TFA
    		Agonist
    Neuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC50=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.
    Neuropeptide S(Rat) TFA
  • HY-P1135A
    M1145 TFA
    		Agonist
    M1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin.
    M1145 TFA
  • HY-P1818
    Neuropeptide Y (22-36)
    Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y2 receptor and retains subnanomolar affinity for the Y2 receptor.
    Neuropeptide Y (22-36)
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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